Rimonabant works on a newly-discovered system in the brain which is involved in motivation and control of appetite as well as the urge to smoke.
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This agent was tested in 2 large phase 3 trials: (1) Rimonabant in Obesity (RIO-LIPIDS), which examined the use of the drug in patients with obesity/metabolic syndrome, and (2) Studies With Rimonabant and Tobacco Use (STRATUS-US), which evaluated the drug in patients attempting smoking cessation.
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